Reducing dentine hypersensitivity.
GLUMA Desensitizer and GLUMA Desensitizer PowerGel contain glutardialdehyde and HEMA ((2-Hydroxyethyl)methacrylate). HEMA enables glutardialdehyde to penetrate up to 200μm into the dentine tubuli3. Inside the tubuli, glutardialdehyde reacts with the proteins present in the dentine liquor. The proteins precipitate and form protein plugs which close the dentine tubuli. This protein coagulation leads to the polymerisation of HEMA4. Because of these coagulated proteins (protein septa), the permeability of the dentine is significantly reduced5 and movements of dentine liquor inside the tubuli or other stimulating effects are lessened. GLUMA Desensitizer and GLUMA Desensitizer PowerGel function within the dentine tubuli and therefore do not interfere with adhesive treatments. They do not create a layer on the dentine surface. Other studies have shown further benefits from glutardialdehyde. It inhibits enzymes (MMPs) within the dentine that degrade the hybrid layer of adhesives over time6. Apart from this, glutardialdehyde has also demonstrated its potential for cavity disinfection7. Last but not least, it increases the strength of the dentine and may lead to more durable bonding8.
3 Schüpbach P et al.: Closing of dentinal tubules by Gluma desensitizer. Eur J Oral Sci 1997; 105: 414-421.
4 Qin C et. al.: Spectroscopic investigation of the function of aqueous 2-hydroxyethylmethacrylate/glutaraldehyde solution as a dentin desensitizer. Eur J Oral Sci 114, 2006:354-9.
5 Ishihata H et al.: In vitro dentin permeability after application of Gluma® desensitizer as aqueous solution or aqueous fumed silica dispersion. J Appl Oral Sci 19(2), 2011:147-53.
6 Sabatini C et al.: Inhibition of endogenous human dentin MMPs by Gluma. Dental Mat 30, 2014: 752-8.
7 Felton D et al.: Inhibition of bacterial growth under composite restorations following GLUMA pretreatment. JDR, 68 (3), 1989: 491-5.
8 Bedran-Russo AK et al.: Changes in stiffness of demineralized dentin following application of collagen cross-linkers. J of Biomedical Materials Research Part B: Applied Biomaterials, 86 (B), 2008: 330-4.